4/22/2023 0 Comments What is cccp on heli![]() ![]() ![]() Akin to the numerous tethers between the outer membrane and other organelles, there is an IM/OM scaffold termed the mitochondrial contact site and cristae organizing system (MICOS) this scaffold is also crucial for cristae junction formation ( Alkhaja et al., 2012 Harner et al., 2011 Hoppins et al., 2011 Itoh et al., 2013 Jans et al., 2013 von der Malsburg et al., 2011). Similarly, PS import from the OM to the IM in yeast is ATP-independent and does not require either a functional membrane potential or oxidative phosphorylation machinery ( Achleitner et al., 1995, 1999 Gnamusch et al., 1992). ![]() Since both compounds are uncouplers that disrupt oxidative phosphorylation, this suggests that dinitrophenol impairs PS uptake by either disturbing IM/OM contacts or increasing the distance between these two membranes ( Knoll and Brdiczka, 1983). In mammals, dinitrophenol but not carbonyl cyanide m-chlorophenyl hydrazone inhibits PS import from the OM to the IM ( Hovius et al., 1992). Claypool, in International Review of Cell and Molecular Biology, 2016 3.2.3.2 Within Mitochondria ![]()
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